Blar i forfatter "Sitras, Vasilis"

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    • Coronary flow reserve in pregnant rats with increased left ventricular afterload 

      Songstad, Nils Thomas; Serrano, Maria; Sitras, Vasilis; Johansen, David; Ytrehus, Kirsti; Acharya, Ganesh (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-07-09)
      Background Coronary flow reserve (CFR) is used as a measure of coronary endothelial function. We investigated the effect of increased afterload on CFR of pregnant and non-pregnant rats. Methods Afterload increase in Wister rats (both pregnant and non-pregnant) was achieved by the infusion of angiotensin II (Ang II) for ~10 days or by subjecting them to transverse aortic constriction (TAC) ...

    • Differences in gene expression between first and third trimester human placenta : a microarray study. 

      Sitras, Vasilis; Fenton, Christopher Graham; Paulssen, Ruth H; Vårtun, Åse; Acharya, Ganesh (Journal article; Tidsskriftartikkel; Peer reviewed, 2012)
      The human placenta is a rapidly developing organ that undergoes structural and functional changes throughout the pregnancy. Our objectives were to investigate the differences in global gene expression profile, the expression of imprinted genes and the effect of smoking in first and third trimester normal human placentas. Placental samples were collected from 21 women with uncomplicated pregnancies ...

    • Gene expression profile of normal and compromised placentas 

      Sitras, Vasilis (Doctoral thesis; Doktorgradsavhandling, 2009-06-26)
      <b>Objective</b> <br>Placenta has an important function of sustaining life in utero. Role of placental gene expression in the physiology of parturition and pathogenesis of pregnancy disorders are poorly understood. The aims of this thesis were to: <br>1. Investigate the effect of labor on global gene expression profile of normal placentas <br>2. Compare placental gene expression profile of ...

    • Laeverin Protein Expression in Normal and Preeclamptic Placentas using Tissue Microarray Analysis 

      Nystad, Mona; Sitras, Vasilis; Nordbakken, Cecilie Valborg; Pedersen, Mona Irene; Acharya, Ganesh (Journal article; Tidsskriftartikkel; Peer reviewed, 2018-01-21)
      <p><i>Introduction - </i>Laeverin is a placenta‐specific protein that is normally expressed in the plasma membrane of human trophoblasts. In previous studies, we showed higher expression levels of laeverin gene in preeclamptic compared with normal placentas and found that laeverin protein was ectopically expressed in the cytoplasm of the preeclamptic placentas. Our objective was to investigate ...

    • Longitudinal reference ranges for maternal plasma laeverin, and its role as a potential biomarker of preeclampsia 

      Nystad, Mona; Sitras, Vasilis; Flo, Kari; Widnes, Christian; Vårtun, Åse; Wilsgaard, Tom; Acharya, Ganesh (Journal article; Tidsskriftartikkel; Peer reviewed, 2016-11-25)
      Background: Laeverin is a placenta-specific membrane-bound aminopeptidase. In this study we wanted to: 1) serially measure plasma levels of laeverin in healthy women during the second half of pregnancy and postpartum, 2) determine whether laeverin is differently expressed at 22–24 weeks in women who later develop preeclampsia compared to controls, 3) compare laeverin protein expression in placenta ...

    • Platelet alloimmunization is associated with low grade chronic histiocytic intervillositis - A new link to a rare placental lesion? 

      Nedberg, Nora Hersoug; Turowski, Gitta Erika; Guz, Katarzyna; Przytuła, Ewa; Uhrynowska, Małgorzata; Roald, Borghild; Husebekk, Anne; Sitras, Vasilis; Nystad, Mona; Dębska, Marzena; Brojer, Ewa; Tiller, Heidi (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-23)
      <i>Introduction</i> - Maternal alloimmunization against human platelet antigen (HPA)-1a has been implied to mediate both reduced birth weight and chronic placental inflammation. Fetal growth restriction is associated with different types of chronic inflammation in the placenta, mainly chronic histiocytic intervillositis and chronic villitis. The aim of this prospective study was to do a systematic ...